Pioneering Vascular Access Research: Engineering, Translation, and Patient Outcomes.
Our lab integrates medicine, engineering, and bioscience to improve hemodialysis vascular access and vascular health in chronic kidney disease — from bedside to bench to bedside.
Revolutionizing Heart Health:
Hemodialysis Vascular Access Dysfunction and Cardiovascular Disease in CKD
Our research focuses on hemodialysis vascular access dysfunction, hemodynamics and wall shear stress in arteriovenous fistula maturation, and cardiovascular disease in chronic kidney disease (CKD) — translating discoveries from bedside to bench and back to improve outcomes for patients.
About Shiu LabOur Research
Shiu Lab focuses on advancing our understanding of hemodialysis vascular access dysfunction and cardiovascular disease in chronic kidney disease (CKD), integrating medicine, engineering, and bioscience through blood-flow imaging, computational modeling, and translational studies.
Featured Publications
Selected publications from the Shiu Lab on hemodialysis vascular access hemodynamics, arteriovenous fistula maturation, and vascular health in chronic kidney disease.
Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula — He Y et al., Scientific Reports. 2025;15:6131.
Differential hemodynamics between arteriovenous fistulas with or without intervention before successful use — Northrup H et al., Frontiers in Cardiovascular Medicine. 2022;9:1001267.
Natural vascular scaffolding treatment promotes outward remodeling during arteriovenous fistula development in rats — Shiu YT et al., Frontiers in Bioengineering and Biotechnology. 2021;9:622617.
Analyses of hemodialysis arteriovenous fistula geometric configuration and its associations with maturation and reintervention — He Y et al., Journal of Vascular Surgery. 2021;73(5):1778-1786.e1.
Mentorship and Training
Dr. Shiu has trained over 50 trainees — visiting scholars, PhD students, MS students, and undergraduates.
She received the 2023 University of Utah Office of Undergraduate Research Award for mentoring. The lab is actively recruiting new students and postdocs — contact Y.Shiu@hsc.utah.edu.
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